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However, these technologies can be both expensive and invasive, and their accessibility is limited in many clinical settings. Demographic variables age, gender, education, and APOE status and neuropsychological test scores were used as predictors in an ML algorithm. For generalizability, results were further checked by randomly dividing the data into training sets and test sets and checking predictive performances by fold cross-validation. The area under the curve of the receiver operating characteristic curve was 0. More specifically, it could be a very brief screening tool in various settings to recruit participants with potential biomarker evidence of AD brain pathology. These identified individuals would be valuable participants in secondary prevention trials aimed at detecting an anti-amyloid drug effect in the non-demented population. However, these processes have several limitations.
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Balasekaran, Tanya K. Sattelberger, and Frederic Poineau. Todorova, C T. Sattelberger, and F Poineau.
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Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. It has a growing spectrum of acknowledged roles in immunity, aging, development, neurodegeneration, and cancer biology. With such a multitude of innate and adaptive immunity functions, the study of autophagy in immunity is one of the most rapidly growing fields of contemporary immunological research. This book introduces the reader to the fundamentals of autophagy, guides a novice and the well-informed reader alike through different immunological aspects of autophagy as well as the countermeasures used by highly adapted pathogens to fight autophagy, and provides the expert with the latest, up-to-date information on the specifics of the leading edge of autophagy research in infection and immunity.
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